🧬Tidera Health

Tidera provides educational trial discovery tools and does not provide medical advice or determine eligibility. Always discuss options with your care team.

Clinical Trials for Mental Health — Find Recruiting Psychiatry Studies

Search trials for depression, anxiety, PTSD, bipolar disorder, schizophrenia, ADHD, and other mental health conditions.

🔍 Search Mental Health (Psychiatry) Trials →

About Mental Health (Psychiatry) Clinical Trials

Mental health clinical trials are testing a new generation of treatments: rapid-acting antidepressants, psychedelic-assisted therapies, ketamine protocols, transcranial magnetic stimulation, and digital therapeutics. Treatment-resistant depression is the most active sub-area, with multiple novel mechanisms in Phase 2 and 3 development.

Browse by Condition

Depression (MDD)

Search treatment-resistant depression, MDD, and novel antidepressant trials matched to your treatment history.

Find trials →

Bipolar Disorder

Search bipolar I, bipolar II, mania, and bipolar depression trials matched to your current episode and treatment history.

Find trials →

PTSD

Search trauma-focused, MDMA-assisted, and novel PTSD therapy trials — matched to your treatment history.

Find trials →

Anxiety Disorders

Search generalized anxiety, social anxiety, and panic disorder trials — matched to your treatment history.

Find trials →

Schizophrenia

Search antipsychotic, cognitive, and negative symptom schizophrenia trials — matched to your treatment history.

Find trials →

ADHD

Search adult and pediatric ADHD trials for stimulant, non-stimulant, and digital interventions.

Find trials →

Browse all conditions →

Quick Search by Condition

🔍 major depressive disorder🔍 treatment-resistant depression🔍 PTSD🔍 bipolar disorder🔍 anxiety disorder

Learning Center: Mental Health (Psychiatry)

Condition Guides11 min

Clinical Trials for Depression and Treatment-Resistant Depression in 2025

→
Condition Guides10 min

Clinical Trials for Mental Health: Depression, Anxiety, PTSD, and More

→
Condition Guides9 min

PTSD Clinical Trials: MDMA-Assisted Therapy, Stellate Ganglion Block, and More

→
View all learning center articles →

Frequently Asked Questions: Mental Health (Psychiatry) Clinical Trials

What is treatment-resistant depression (TRD) and are there specific trials?▾
TRD is typically defined as inadequate response to at least 2 adequate antidepressant trials. Many clinical trials specifically target TRD patients with novel mechanisms including ketamine/esketamine, psilocybin-assisted therapy, TMS, and glutamate modulators.
Are psychedelic clinical trials legitimate?▾
Yes. MDMA-assisted therapy for PTSD and psilocybin for depression are in FDA-regulated Phase 2 and Phase 3 trials at leading academic medical centers. These are tightly controlled research protocols, not recreational programs.
Do mental health trials require stopping current medications?▾
Frequently yes — most psychiatric trials require washout periods from current medications, which can range from 1–4 weeks depending on the drug's half-life. This must be done under physician supervision and represents a significant patient burden.

Data source: All trial data sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is independent and not affiliated with ClinicalTrials.gov or the NLM.