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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

PsychiatryICD-10: F32

Find Recruiting Clinical Trials for Depression

Search treatment-resistant depression, MDD, and novel antidepressant trials matched to your treatment history.

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About Depression (MDD)

Major depressive disorder (MDD) is one of the most common mental health conditions worldwide, characterized by persistent low mood, loss of interest, fatigue, and cognitive difficulties. Standard treatments include antidepressants (SSRIs, SNRIs, TCAs), psychotherapy, and augmentation strategies. Treatment-resistant depression (TRD) — defined as failure of two or more adequate antidepressant trials — affects approximately one-third of patients.

What Types of Depression (MDD) Clinical Trials Exist?

Depression clinical trials test new antidepressant mechanisms (glutamate modulators, rapid-acting agents), augmentation strategies, psychedelic-assisted therapy protocols, neuromodulation (TMS, ECT variants), and digital therapeutics. Treatment-resistant depression trials specifically recruit patients who have not responded to established therapies.

Find Recruiting Depression (MDD) Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for depression?▾
Recruiting depression trials include novel antidepressants (glutamate modulators, GABA agents), ketamine/esketamine protocols, psychedelic-assisted therapy, augmentation strategies, neuromodulation, and digital CBT studies.
What is treatment-resistant depression and are there specific trials?▾
Treatment-resistant depression (TRD) is typically defined as inadequate response to at least two adequate antidepressant trials. Many clinical trials specifically target TRD with novel mechanisms, neuromodulation, or ketamine-based therapies.
Does depression severity affect clinical trial eligibility?▾
Yes. Most depression trials require a minimum severity score on standardized scales such as the HAMD-17 or MADRS, along with confirmation of a current depressive episode. Some trials exclude patients with active suicidal ideation.

Related Conditions

Bipolar DisorderPTSDAnxiety

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.