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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

PsychiatryICD-10: F20

Find Recruiting Clinical Trials for Schizophrenia

Search antipsychotic, cognitive, and negative symptom schizophrenia trials — matched to your treatment history.

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About Schizophrenia

Schizophrenia is a chronic, severe mental disorder affecting approximately 24 million people worldwide. It is characterized by positive symptoms (hallucinations, delusions, disorganized thinking), negative symptoms (flat affect, avolition, social withdrawal), and cognitive impairment. While antipsychotics effectively control positive symptoms in most patients, negative symptoms and cognitive deficits remain largely undertreated and represent the primary unmet need driving clinical trial activity.

What Types of Schizophrenia Clinical Trials Exist?

Schizophrenia trials span several domains: novel antipsychotics with improved tolerability and metabolic profiles, agents targeting negative symptoms (muscarinic agonists, D1/D2 balance modulators), cognitive remediation trials, long-acting injectable (LAI) formulations, and biomarker-based patient stratification studies. PANSS (Positive and Negative Syndrome Scale) and BPRS scores are standard eligibility tools. Many trials require stable antipsychotic background therapy and a defined symptom severity range.

Find Recruiting Schizophrenia Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for schizophrenia?▾
Recruiting schizophrenia trials include novel antipsychotics, muscarinic receptor agonists targeting negative symptoms and cognition, cognitive remediation programs, long-acting injectable formulations, digital monitoring studies, and biomarker research. The negative symptom and cognition space is the most active area of drug development.
What are negative symptoms and why are they important in trials?▾
Negative symptoms include flat affect, poverty of speech, avolition, anhedonia, and social withdrawal. Unlike positive symptoms (hallucinations, delusions), negative symptoms respond poorly to standard antipsychotics and are the primary driver of long-term disability. Many trials specifically target negative symptoms as the primary endpoint.
Can I join a schizophrenia trial while on an antipsychotic?▾
Many schizophrenia trials allow continued background antipsychotic therapy and test an add-on agent. Others require switching to a study medication with appropriate washout. Stability — defined as no hospitalization or significant dose change in the preceding 3–6 months — is typically required for enrollment.

Related Conditions

Bipolar DisorderDepression (MDD)Anxiety Disorders

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.