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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

PsychiatryICD-10: F43.1

Find Recruiting Clinical Trials for PTSD

Search trauma-focused, MDMA-assisted, and novel PTSD therapy trials — matched to your treatment history.

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About PTSD

Post-traumatic stress disorder (PTSD) affects approximately 3.5% of US adults annually and up to 20% of veterans exposed to combat. It is characterized by intrusive symptoms (flashbacks, nightmares), avoidance, negative alterations in cognition and mood, and hyperarousal following exposure to traumatic events. Approved pharmacotherapies include sertraline and paroxetine (SSRIs), but only 20–30% of patients achieve full remission with medication alone. Trauma-focused psychotherapies (CPT, PE, EMDR) are first-line but access-limited.

What Types of PTSD Clinical Trials Exist?

PTSD trials are among the most active in psychiatry. MDMA-assisted therapy trials have shown breakthrough results in Phase III and represent a landmark development in the field. Other trials test stellate ganglion block, prolonged exposure variants, novel pharmacotherapies (prazosin, propranolol, cannabis-based medicines), neuromodulation (TMS, transcranial direct current stimulation), and virtual reality exposure therapy. Most trials require a PTSD diagnosis confirmed by PCL-5 or CAPS-5, a minimum symptom severity threshold, and index trauma documentation.

Find Recruiting PTSD Trials Near You

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for PTSD?▾
Recruiting PTSD trials include MDMA-assisted psychotherapy protocols, stellate ganglion block trials, novel pharmacotherapy studies (prazosin, cannabis-based medicines), trauma-focused psychotherapy variations, TMS neuromodulation, virtual reality exposure therapy, and digital therapeutics.
What is MDMA-assisted therapy for PTSD?▾
MDMA-assisted therapy combines MDMA (3,4-methylenedioxymethamphetamine) with psychotherapy sessions. Phase III trials showed 67–71% of participants no longer met PTSD diagnostic criteria after treatment. This approach involves a small number of MDMA sessions embedded within a broader psychotherapy program, conducted in a clinical setting with trained therapists.
Does military service or trauma type affect trial eligibility?▾
Some PTSD trials specifically enroll military veterans or first responders; others enroll civilians with any index trauma. Trauma type (combat, sexual assault, accident, natural disaster) may affect eligibility depending on the trial design. Index trauma documentation and CAPS-5 structured interview are standard screening tools.

Related Conditions

Depression (MDD)Anxiety DisordersBipolar Disorder

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.