Tidera provides educational trial discovery tools and does not provide medical advice or determine eligibility. Always discuss options with your care team.

Clinical Trials for GI Conditions — Find Recruiting Gastroenterology Studies

Search trials for Crohn's disease, ulcerative colitis, IBS, eosinophilic esophagitis, NASH, and other GI conditions.

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About Gastroenterology Clinical Trials

Gastroenterology clinical trials are highly active, particularly in IBD (Crohn's disease and ulcerative colitis), which now has multiple approved biologic classes with new agents in late-stage development. NASH/MAFLD has become one of the busiest areas in clinical research, and eosinophilic esophagitis has recently seen its first approved therapy with more in the pipeline.

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Crohn's Disease

Search IBD studies across biologics, small molecules, and induction/maintenance trials — matched to your treatment history.

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Ulcerative Colitis

Search biologic, JAK inhibitor, S1P modulator, and induction/maintenance UC trials matched to your disease extent and treatment history.

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Quick Search by Condition

🔍 Crohn's disease 🔍 ulcerative colitis 🔍 irritable bowel syndrome 🔍 NASH 🔍 eosinophilic esophagitis

Learning Center: Gastroenterology

Condition Guides10 min

IBD Clinical Trials in 2025: Crohn's Disease and Ulcerative Colitis Studies

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Condition Guides8 min

IBD Clinical Trials for Children and Adolescents: Pediatric Crohn's and UC Studies

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View all learning center articles →

Frequently Asked Questions: Gastroenterology Clinical Trials

What IBD clinical trials are available for anti-TNF failure patients?▾

Many IBD trials specifically recruit patients who have failed or been intolerant to anti-TNF biologics. These trials test newer mechanisms including IL-12/23, IL-23, S1P modulators, and JAK inhibitors. Being 'anti-TNF experienced' is often an inclusion criterion, not a barrier.

Do IBD trials require endoscopy confirmation?▾

Yes — most Crohn's and UC trials require endoscopic confirmation of active disease at baseline, with specific endoscopic activity score thresholds (e.g., SES-CD ≥6 for Crohn's, Mayo endoscopic subscore ≥2 for UC). This typically means a colonoscopy at screening.

Data source: All trial data sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is independent and not affiliated with ClinicalTrials.gov or the NLM.