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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

RheumatologyICD-10: M10

Find Recruiting Clinical Trials for Gout

Search urate-lowering, flare prevention, and refractory gout trials — matched to your uric acid levels and treatment history.

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About Gout

Gout is the most common inflammatory arthritis, affecting over 9 million Americans. It results from hyperuricemia (elevated serum uric acid) leading to monosodium urate crystal deposition in joints and soft tissues, causing acute flares of intense joint pain, tophi formation, and progressive joint damage. Despite highly effective urate-lowering therapies (allopurinol, febuxostat, probenecid), a significant proportion of patients have refractory gout with persistently elevated urate levels and recurrent flares despite optimized standard therapy.

What Types of Gout Clinical Trials Exist?

Gout clinical trials test new urate-lowering agents, novel XO inhibitors, URAT1 inhibitors with improved efficacy, IL-1 inhibitors for acute flare management, and interventions for tophaceous gout. Refractory gout trials (for patients who fail standard urate-lowering therapy) test pegloticase combinations with immunomodulation to reduce immunogenicity. Serum uric acid thresholds (typically ≥6 or ≥8 mg/dL) and flare frequency criteria are standard eligibility requirements.

Find Recruiting Gout Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for gout?▾
Recruiting gout trials include new urate-lowering agents, URAT1 inhibitor studies, IL-1 inhibitor trials for acute flare prevention, pegloticase with immunomodulation protocols for refractory gout, and lifestyle intervention studies. Refractory and tophaceous gout trials are particularly active.
What is refractory gout and are there specific trials?▾
Refractory gout is defined as persistently elevated serum uric acid (typically ≥6 mg/dL on target) or recurrent flares (≥3/year) despite optimized urate-lowering therapy, or intolerance to standard agents. Pegloticase (a pegylated uricase) with immunomodulation is the most active trial area for this population.
What uric acid level do I need to qualify for gout trials?▾
Most urate-lowering trials require a serum uric acid ≥6 mg/dL (the treatment target) or ≥8 mg/dL for more severe disease trials, measured off or on suboptimal urate-lowering therapy. Bring your most recent uric acid lab result to any screening visit.

Related Conditions

Rheumatoid ArthritisPsoriatic ArthritisChronic Kidney Disease

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.