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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

RheumatologyICD-10: M19

Find Recruiting Clinical Trials for Osteoarthritis

Search knee, hip, and hand osteoarthritis trials — pain management, disease-modification, and regenerative approaches.

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About Osteoarthritis

Osteoarthritis (OA) is the most prevalent joint disease globally, affecting over 500 million people. It is a complex disease of cartilage degradation, subchondral bone remodeling, synovial inflammation, and progressive joint failure. The knee and hip are most commonly affected, with hand and spine OA also highly prevalent. Current management is largely symptomatic (analgesics, NSAIDs, intra-articular injections); no disease-modifying OA drug (DMOAD) is currently approved, representing the central unmet need and the primary driver of clinical trial activity.

What Types of Osteoarthritis Clinical Trials Exist?

OA clinical trials are experiencing a renaissance following several near-miss DMOAD trials. Active programs include lorecivivint (Wnt pathway modulator), sprifermin (FGF-18 for cartilage), hydroxypropyl chitosan injection, anti-nerve growth factor antibodies (tanezumab, fasinumab — for pain), bone-targeting bisphosphonate studies, and multiple regenerative approaches including platelet-rich plasma and mesenchymal stem cell studies. WOMAC, KOOS, and VAS pain scales are standard eligibility and endpoint measures. Kellgren-Lawrence radiographic grade typically determines eligibility.

Find Recruiting Osteoarthritis Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for osteoarthritis?▾
Recruiting OA trials include disease-modifying drug studies (lorecivivint, sprifermin, bone-targeting agents), pain management trials (anti-NGF antibodies, novel analgesics), intra-articular injection studies (PRP, hyaluronic acid formulations, stem cells), and surgical comparison trials. Knee OA has the most active trial landscape.
What is a DMOAD and why does it matter?▾
A disease-modifying osteoarthritis drug (DMOAD) would slow or halt cartilage degradation and joint damage — not just reduce pain. No DMOAD is currently approved. Several are in Phase II/III trials. If approved, DMOADs would represent the first treatments that change the natural history of OA rather than just managing symptoms.
Does my X-ray grade affect osteoarthritis trial eligibility?▾
Yes. Kellgren-Lawrence (KL) grading from X-ray is the standard OA staging tool (grades 0–4). Most drug trials target KL grade 2–3 (moderate OA with joint space narrowing). Severe OA (KL grade 4, marked joint space loss or bone-on-bone) may be excluded from some trials and targeted by surgical comparison studies.

Related Conditions

Rheumatoid ArthritisPsoriatic ArthritisObesity

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.