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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

NeurologyICD-10: G43

Find Recruiting Clinical Trials for Migraine

Search episodic and chronic migraine trials — CGRP inhibitors, acute treatment, and prevention studies.

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About Migraine

Migraine is a complex neurological disorder affecting approximately 1 billion people worldwide and 39 million Americans — one of the most prevalent disabling conditions globally. It is characterized by recurrent episodes of moderate-to-severe headache (typically unilateral, throbbing) accompanied by nausea, photophobia, and phonophobia, lasting 4–72 hours. Chronic migraine is defined as ≥15 headache days per month with ≥8 migraine days. The CGRP (calcitonin gene-related peptide) pathway has been a transformative target, producing effective preventive (CGRP monoclonal antibodies) and acute (gepants, ditans) therapies with good tolerability.

What Types of Migraine Clinical Trials Exist?

Migraine trials are active in both prevention and acute treatment. Preventive trials test next-generation CGRP antibodies, CGRP receptor antagonist oral preventives (atogepant, rimegepant for prevention), non-pharmacological neurostimulation devices, and novel targets (PACAP, 5-HT1F). Acute treatment trials test new gepant formulations, intranasal and sublingual delivery routes, and combinations. Monthly migraine day count, prior preventive medication failures, and headache diary documentation are standard eligibility requirements.

Find Recruiting Migraine Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for migraine?▾
Recruiting migraine trials include next-generation CGRP antibodies, oral CGRP receptor antagonist prevention trials, novel acute treatment formulations, neurostimulation device studies (TMS, e-TNS, VNS), combination preventive therapy trials, and menstrual migraine-specific studies.
What is chronic migraine and what trials target it?▾
Chronic migraine is defined as ≥15 headache days per month (≥3 months) with ≥8 fulfilling migraine criteria. Chronic migraine has the most active preventive trial landscape, including onabotulinumtoxinA (BOTOX) optimization, CGRP antibody intensification, and combination approaches. Episodic migraine (≤14 headache days/month) trials focus on conversion prevention.
How do I document my migraine frequency for trial eligibility?▾
Most migraine trials require a 28–90 day prospective headache diary before screening to document monthly migraine day frequency, acute medication use, and headache characteristics. Overuse of acute medications (medication overuse headache, defined as ≥10–15 days/month use) may be an exclusion criterion or separate enrollment category in some trials.

Related Conditions

Parkinson's DiseaseEpilepsyAnxiety Disorders

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.