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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

Infectious DiseaseICD-10: B20

Find Recruiting Clinical Trials for HIV

Search HIV treatment, long-acting therapy, cure research, and comorbidity trials — matched to your viral load, CD4 count, and ART history.

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About HIV / AIDS

HIV (human immunodeficiency virus) infection, if untreated, progresses to AIDS (acquired immunodeficiency syndrome). Antiretroviral therapy (ART) has transformed HIV from a fatal disease to a manageable chronic condition, with people on effective ART having near-normal life expectancy. Approximately 1.2 million Americans and 38 million people globally live with HIV. Despite excellent virologic control with modern ART (95%+ of treated patients achieve undetectable viral load), challenges remain including daily pill burden, long-term metabolic and cardiovascular toxicity, HIV-associated comorbidities, and the quest for HIV remission or functional cure.

What Types of HIV / AIDS Clinical Trials Exist?

HIV trials are active across multiple domains. Long-acting injectable ART trials extend cabotegravir + rilpivirine to longer dosing intervals (monthly, bimonthly, every 6 months) and test novel long-acting formulations. Broadly neutralizing antibody (bNAb) combination trials aim for HIV remission off ART. Cure research trials test latency-reversing agents, gene editing approaches, and therapeutic vaccines. HIV comorbidity trials address cardiovascular disease, metabolic syndrome, neurocognitive impairment, and aging-related conditions in people with HIV. CD4 count, viral load (suppressed vs. detectable), ART regimen, and nadir CD4 history determine eligibility.

Find Recruiting HIV / AIDS Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

Search HIV / AIDS Trials →

Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for HIV?▾
Recruiting HIV trials include long-acting injectable ART optimization (6-month dosing intervals), broadly neutralizing antibody combinations, latency reversal + immune clearance ("kick and kill") strategies, therapeutic vaccines, gene therapy approaches (CCR5 disruption, CAR-T targeting HIV), and trials addressing HIV-associated comorbidities (cardiovascular, neurocognitive, metabolic).
Can I join an HIV trial if my viral load is undetectable?▾
Yes — many HIV trials specifically enroll virologically suppressed individuals (undetectable viral load on stable ART). Long-acting ART trials, cure research, and comorbidity trials predominantly enroll suppressed patients. Trials testing new treatment-naive regimens or rescue therapy enroll patients with detectable viremia or treatment failure.
What is HIV cure research and how does it work?▾
HIV cure research aims to eliminate the latent HIV reservoir — infected cells that are silently carrying HIV DNA despite ART suppression. Approaches include latency reversal agents (to expose latent virus for immune clearance), broadly neutralizing antibodies (to bind and eliminate exposed virus), therapeutic vaccines (to train the immune system to control HIV), and gene editing (to disrupt HIV integration or CCR5 entry receptor). Full eradication remains elusive but functional remission (durable control off ART) is the near-term goal.

Related Conditions

Hepatitis CDepression (MDD)Chronic Kidney Disease

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.