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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

CardiologyICD-10: I25

Find Recruiting Clinical Trials for Coronary Artery Disease

Search CAD, angina, post-MI, and atherosclerosis trials — matched to your cardiac history and current therapy.

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About Coronary Artery Disease

Coronary artery disease (CAD) is the leading cause of death globally, caused by atherosclerotic plaque buildup in coronary arteries leading to reduced blood flow, angina, myocardial infarction (heart attack), and heart failure. Despite excellent standard therapies (statins, aspirin, beta-blockers, ACE inhibitors, PCSK9 inhibitors), residual cardiovascular risk remains substantial. Approximately 800,000 Americans experience a myocardial infarction annually, and 18 million Americans live with diagnosed CAD.

What Types of Coronary Artery Disease Clinical Trials Exist?

CAD clinical trials are among the largest-scale in cardiovascular medicine. Active trial areas include novel lipid-lowering agents (inclisiran, bempedoic acid, PCSK9 inhibitors), anti-inflammatory approaches (colchicine for residual inflammatory risk, IL-6 inhibitors), revascularization optimization (PCI vs. CABG comparisons, FFR-guided PCI), antiplatelet intensification and de-escalation, GLP-1 receptor agonist cardiovascular benefit extension, and cardiac rehabilitation. MACE (major adverse cardiovascular events) composites of death, MI, and stroke are standard primary endpoints.

Find Recruiting Coronary Artery Disease Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for coronary artery disease?▾
Recruiting CAD trials include novel lipid-lowering agents (PCSK9 inhibitors, inclisiran, bempedoic acid), anti-inflammatory therapies (colchicine, IL-6 inhibitors), antiplatelet strategy optimization, revascularization comparison studies, GLP-1 agonist secondary prevention trials, and cardiac rehabilitation digital health programs.
Does having had a prior heart attack affect my CAD trial eligibility?▾
Prior MI is a common inclusion criterion for secondary prevention trials — these trials specifically enroll high-risk patients with established CAD. Most secondary prevention trials require documented prior MI, PCI, or CABG within a defined timeframe. Stable CAD without prior MI qualifies for primary prevention-adjacent and lipid-lowering trials.
What does LDL cholesterol level mean for CAD trial eligibility?▾
LDL-C levels are a primary stratification variable. Most lipid-lowering trials require LDL-C ≥70 mg/dL (1.8 mmol/L) on maximally tolerated statin therapy, confirming residual risk despite standard treatment. Some trials enroll statin-intolerant patients specifically. Bring recent lipid panel results to any screening visit.

Related Conditions

Heart FailureAtrial FibrillationType 2 Diabetes

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.