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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

CardiologyICD-10: I48

Find Recruiting Clinical Trials for Atrial Fibrillation

Search AFib rhythm control, ablation, anticoagulation, and stroke prevention trials — matched to your AFib type and risk profile.

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About Atrial Fibrillation

Atrial fibrillation (AFib) is the most common sustained cardiac arrhythmia, affecting over 33 million people worldwide and 6 million Americans. It causes an irregular, often rapid heart rate that can lead to heart failure, stroke, and reduced quality of life. Management strategies include rate control (beta-blockers, calcium channel blockers), rhythm control (antiarrhythmics, cardioversion, catheter ablation), and anticoagulation for stroke prevention. Despite advances, AFib recurrence after ablation remains a major challenge and the primary driver of trial activity.

What Types of Atrial Fibrillation Clinical Trials Exist?

AFib clinical trials are highly active across multiple domains. Rhythm control trials test newer antiarrhythmic agents (etripamil, budiodarone), catheter ablation protocol optimization (cryoablation vs. RF vs. pulsed field ablation), and post-ablation management. Rate control trials test novel rate-controlling agents. Anticoagulation trials evaluate novel factor XIa inhibitors with improved bleeding profiles versus DOACs. AF burden and symptom reduction trials use wearable monitoring. CHA₂DS₂-VASc score, AF type (paroxysmal, persistent, long-standing persistent), and prior ablation history are key eligibility variables.

Find Recruiting Atrial Fibrillation Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for atrial fibrillation?▾
Recruiting AFib trials include catheter ablation protocol optimization (pulsed field ablation, RF vs. cryo comparison), novel antiarrhythmic agents, factor XIa inhibitors for anticoagulation with lower bleeding risk, rate control studies, wearable device monitoring studies, and lifestyle/risk factor modification trials (particularly weight loss and alcohol reduction).
Does my AFib type (paroxysmal vs. persistent) affect trial eligibility?▾
Yes significantly. Paroxysmal AFib (self-terminating episodes <7 days) and persistent AFib (episodes lasting >7 days requiring intervention) have different trial landscapes. Ablation trials often specify AFib type and duration. Long-standing persistent AFib (>12 months continuous) has lower ablation success rates and is often a separate trial population.
Can I join an AFib trial if I am on a blood thinner?▾
Many AFib trials allow continuation of anticoagulation, particularly studies of ablation, rate control, or rhythm control drugs. Anticoagulation trials test alternatives to current blood thinners and may require stopping current anticoagulation with bridging. CHA₂DS₂-VASc score (stroke risk) affects anticoagulation trial eligibility thresholds.

Related Conditions

Heart FailureHeart DiseaseHypertension / Cardiovascular

Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.