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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

OB/GYNICD-10: N80

Find Recruiting Clinical Trials for Endometriosis

Search endometriosis pain, fertility, and novel hormone-free treatment trials — matched to your disease stage and prior therapy.

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About Endometriosis

Endometriosis is a chronic gynecological condition in which endometrial-like tissue grows outside the uterus, causing pelvic pain, dysmenorrhea (painful periods), dyspareunia (painful intercourse), and infertility. It affects approximately 190 million women globally (10% of reproductive-age women). Diagnosis is often delayed by 7–10 years from symptom onset. Current treatments include hormonal suppression (combined oral contraceptives, progestins, GnRH agonists/antagonists) and surgical excision, but disease recurrence is common and hormonal therapies affect fertility. A significant unmet need exists for non-hormonal, fertility-preserving treatments.

What Types of Endometriosis Clinical Trials Exist?

Endometriosis trials are increasingly targeting non-hormonal mechanisms. Novel GnRH antagonist oral formulations (relugolix, elagolix extension studies), selective progesterone receptor modulators, anti-inflammatory agents (TNF inhibitors, IL-1 inhibitors), anti-angiogenic approaches, and pain pathway modulators (sodium channel blockers, NK1 antagonists) are in active development. Fertility-preserving approaches and biomarker-based non-invasive diagnostic tools are also in trials. ASRM staging (I–IV), symptom scores (NRS for pain, BSPM), prior surgical history, and hormonal therapy experience determine eligibility.

Find Recruiting Endometriosis Trials Near You

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for endometriosis?▾
Recruiting endometriosis trials include novel GnRH antagonists with add-back hormone therapy (for bone protection), non-hormonal pain management trials (sodium channel modulators, NK1 antagonists), anti-inflammatory biologics, fertility-preservation approaches, non-invasive diagnostic biomarker studies, and surgical technique comparison trials.
Can I join an endometriosis trial if I want to preserve fertility?▾
Yes — fertility preservation is increasingly a design criterion in endometriosis trials, particularly non-hormonal pain trials. Hormonal suppression trials (GnRH antagonists) typically require contraception or are designed for patients not currently seeking pregnancy. Always disclose your fertility goals at screening.
Do I need surgical confirmation of endometriosis for trial eligibility?▾
Historically, laparoscopic visualization with biopsy was required for diagnosis confirmation in trials. Some newer trials accept clinical diagnosis criteria and imaging (transvaginal ultrasound, MRI) especially for deep infiltrating endometriosis and endometriomas. Check individual trial requirements — the standard is evolving away from mandatory surgery for diagnosis.

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Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.