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Educational tool only. Does not confirm eligibility or provide medical advice. Always consult your physician before pursuing any trial.

RheumatologyICD-10: M79.3

Find Recruiting Clinical Trials for Fibromyalgia

Search fibromyalgia pain, fatigue, and central sensitization trials — pharmacological, neuromodulation, and digital health studies.

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About Fibromyalgia

Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties ("fibro fog"). It affects approximately 4 million Americans (2% of the adult population) and is more prevalent in women. Fibromyalgia is a disorder of central pain processing (central sensitization) rather than peripheral inflammation — tissues are structurally normal, but the nervous system amplifies pain signals. FDA-approved treatments include duloxetine, milnacipran, and pregabalin, but fewer than 50% of patients achieve meaningful symptom improvement.

What Types of Fibromyalgia Clinical Trials Exist?

Fibromyalgia trials test new pharmacological targets (sodium channel modulators, NK1 receptor antagonists, low-dose naltrexone, sigma-1 receptor antagonists), non-pharmacological interventions (CBT-based digital platforms, mindfulness, graded exercise programs), transcranial magnetic stimulation and other neuromodulation approaches, and combination mind-body interventions. The Revised Fibromyalgia Impact Questionnaire (FIQR) and Numeric Pain Rating Scale are standard eligibility and endpoint measures. ACR 2010/2016 diagnostic criteria are used to confirm the diagnosis.

Find Recruiting Fibromyalgia Trials Near You

Enter your profile and we'll search ClinicalTrials.gov in real time — matching trials to your age, location, and treatment history. Free, no account required.

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Data from ClinicalTrials.gov · Updated in real time · Educational use only

Frequently Asked Questions

What clinical trials are available for fibromyalgia?▾
Recruiting fibromyalgia trials include novel pharmacological agents (low-dose naltrexone, sigma-1 receptor antagonists, sodium channel modulators), cognitive behavioral therapy digital programs, transcranial magnetic stimulation (TMS), mindfulness-based stress reduction, graded exercise and physical therapy protocols, and combination mind-body intervention studies.
What criteria are used to diagnose fibromyalgia for clinical trials?▾
The ACR 2010/2016 criteria (Widespread Pain Index and Symptom Severity Scale) are standard for trial enrollment — no tender point examination is required. Most trials require a minimum pain severity score (NRS ≥5/10 or FIQR total ≥39) to confirm meaningful disease burden. A history of symptom duration ≥3 months is standard.
Can I join a fibromyalgia trial if I am on current medications?▾
Depends on the trial. Some trials allow stable background medications (antidepressants, pregabalin) and test add-on therapies. Others require washout of existing fibromyalgia treatments. Trials testing new central sensitization targets may require medication-free periods to avoid confounding. Document your current medications and doses carefully.

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Data source: All clinical trial information is sourced from ClinicalTrials.gov, the official U.S. registry maintained by the National Library of Medicine. Tidera Health is an independent educational platform and is not affiliated with ClinicalTrials.gov or the National Library of Medicine. Always verify trial details directly with the research coordinator or your physician.